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Diplegia

MedGen UID:
472941
•Concept ID:
C0221165
•
Disease or Syndrome
Synonym: Bilateral paralysis
SNOMED CT: Diplegia (6481005); Bilateral paralysis (6481005)

Definition

Paralysis affecting corresponding parts on both sides of the body. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiplegia

Professional guidelines

PubMed

Botulinum Toxin in the Management of Children with Cerebral Palsy.
Multani I, Manji J, Hastings-Ison T, Khot A, Graham K
Paediatr Drugs 2019 Aug;21(4):261-281. doi: 10.1007/s40272-019-00344-8. PMID: 31257556Free PMC Article
SELECTIVE DORSAL RHIZOTOMY IN CEREBRAL PALSY: SELECTION CRITERIA AND POSTOPERATIVE PHYSICAL THERAPY PROTOCOLS.
Nicolini-Panisson RD, Tedesco AP, Folle MR, Donadio MVF
Rev Paul Pediatr 2018 Jan-Mar;36(1):9. Epub 2018 Jan 15 doi: 10.1590/1984-0462/;2018;36;1;00005. PMID: 29412426Free PMC Article
The differential diagnosis of spastic diplegia.
Huntsman R, Lemire E, Norton J, Dzus A, Blakley P, Hasal S
Arch Dis Child 2015 May;100(5):500-4. Epub 2014 Nov 18 doi: 10.1136/archdischild-2014-307443. PMID: 25700542

Recent clinical studies

Etiology

Effects of Hippotherapy on Postural Control in Children With Cerebral Palsy: A Systematic Review.
Peia F, Veiga NC, Gomes AP, Santos BND, Marques NMS, Glória IPDS, Goulardins JB
Pediatr Phys Ther 2023 Apr 1;35(2):202-210. Epub 2023 Mar 3 doi: 10.1097/PEP.0000000000000999. PMID: 36867588
Effect of simultaneous proprioceptive-visual feedback on gait of children with spastic diplegic cerebral palsy.
Hussein ZA, Salem IA, Ali MS
J Musculoskelet Neuronal Interact 2019 Dec 1;19(4):500-506. PMID: 31789301Free PMC Article
Feeding children with cerebral palsy and swallowing difficulties.
Arvedson JC
Eur J Clin Nutr 2013 Dec;67 Suppl 2:S9-12. doi: 10.1038/ejcn.2013.224. PMID: 24301008
Idiopathic toe-walking.
Babb A, Carlson WO
S D Med 2008 Feb;61(2):53, 55-7. PMID: 18432151
Neuroimaging in cerebral palsy.
Accardo J, Kammann H, Hoon AH Jr
J Pediatr 2004 Aug;145(2 Suppl):S19-27. doi: 10.1016/j.jpeds.2004.05.018. PMID: 15292883

Diagnosis

Congenital heart defects in CTNNB1 syndrome: Raising clinical awareness.
Sinibaldi L, Garone G, Mandarino A, Iarossi G, Chioma L, Dentici ML, Merla G, Agolini E, Micalizzi A, Mancini C, Niceta M, Macchiaiolo M, Diodato D, Onesimo R, Blandino R, Delogu AB, De Rosa G, Trevisan V, Iademarco M, Zampino G, Tartaglia M, Novelli A, Bartuli A, Digilio MC, Calcagni G
Clin Genet 2023 Nov;104(5):528-541. Epub 2023 Jul 17 doi: 10.1111/cge.14404. PMID: 37455656
X-linked mental deficiency.
des Portes V
Handb Clin Neurol 2013;111:297-306. doi: 10.1016/B978-0-444-52891-9.00035-X. PMID: 23622180
Sjogren-Larsson syndrome.
Dutra LA, Braga-Neto P, Pedroso JL, Povoas Barsottini OG
Adv Exp Med Biol 2012;724:344-50. doi: 10.1007/978-1-4614-0653-2_26. PMID: 22411255
Sjögren-Larsson syndrome.
Gordon N
Dev Med Child Neurol 2007 Feb;49(2):152-4. doi: 10.1111/j.1469-8749.2007.00152.x. PMID: 17254005
The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability.
Eliasson AC, Krumlinde-Sundholm L, Rösblad B, Beckung E, Arner M, Ohrvall AM, Rosenbaum P
Dev Med Child Neurol 2006 Jul;48(7):549-54. doi: 10.1017/S0012162206001162. PMID: 16780622

Therapy

Association of Guillain-Barré syndrome following COVID-19 vaccination.
Chowdhury S, Chowdhury S
Int J Immunopathol Pharmacol 2023 Jan-Dec;37:3946320231199349. doi: 10.1177/03946320231199349. PMID: 37681361Free PMC Article
The Influence of Hippotherapy on the Body Posture in a Sitting Position among Children with Cerebral Palsy.
Matusiak-Wieczorek E, Dziankowska-Zaborszczyk E, Synder M, Borowski A
Int J Environ Res Public Health 2020 Sep 19;17(18) doi: 10.3390/ijerph17186846. PMID: 32961681Free PMC Article
Effect of simultaneous proprioceptive-visual feedback on gait of children with spastic diplegic cerebral palsy.
Hussein ZA, Salem IA, Ali MS
J Musculoskelet Neuronal Interact 2019 Dec 1;19(4):500-506. PMID: 31789301Free PMC Article
Botulinum Toxin in the Management of Children with Cerebral Palsy.
Multani I, Manji J, Hastings-Ison T, Khot A, Graham K
Paediatr Drugs 2019 Aug;21(4):261-281. doi: 10.1007/s40272-019-00344-8. PMID: 31257556Free PMC Article
Cerebral folate deficiency.
Hyland K, Shoffner J, Heales SJ
J Inherit Metab Dis 2010 Oct;33(5):563-70. Epub 2010 Jul 29 doi: 10.1007/s10545-010-9159-6. PMID: 20668945

Prognosis

Molybdenum cofactor deficiency: A natural history.
Spiegel R, Schwahn BC, Squires L, Confer N
J Inherit Metab Dis 2022 May;45(3):456-469. Epub 2022 Mar 3 doi: 10.1002/jimd.12488. PMID: 35192225Free PMC Article
Botulinum Toxin in the Management of Children with Cerebral Palsy.
Multani I, Manji J, Hastings-Ison T, Khot A, Graham K
Paediatr Drugs 2019 Aug;21(4):261-281. doi: 10.1007/s40272-019-00344-8. PMID: 31257556Free PMC Article
Clinical, biochemical, and genetic aspects of Sjögren-Larsson syndrome.
Cho KH, Shim SH, Kim M
Clin Genet 2018 Apr;93(4):721-730. Epub 2017 Sep 17 doi: 10.1111/cge.13058. PMID: 28543186
Idiopathic toe-walking.
Babb A, Carlson WO
S D Med 2008 Feb;61(2):53, 55-7. PMID: 18432151
Cerebral palsy.
Dabney KW, Lipton GE, Miller F
Curr Opin Pediatr 1997 Feb;9(1):81-8. doi: 10.1097/00008480-199702000-00017. PMID: 9088760

Clinical prediction guides

Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis.
Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A
Ultrasound Obstet Gynecol 2022 May;59(5):585-595. doi: 10.1002/uog.24766. PMID: 34529308
Botulinum Toxin in the Management of Children with Cerebral Palsy.
Multani I, Manji J, Hastings-Ison T, Khot A, Graham K
Paediatr Drugs 2019 Aug;21(4):261-281. doi: 10.1007/s40272-019-00344-8. PMID: 31257556Free PMC Article
Congenital and infantile myotonic dystrophy.
Echenne B, Bassez G
Handb Clin Neurol 2013;113:1387-93. doi: 10.1016/B978-0-444-59565-2.00009-5. PMID: 23622362
Idiopathic toe-walking.
Babb A, Carlson WO
S D Med 2008 Feb;61(2):53, 55-7. PMID: 18432151
The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability.
Eliasson AC, Krumlinde-Sundholm L, Rösblad B, Beckung E, Arner M, Ohrvall AM, Rosenbaum P
Dev Med Child Neurol 2006 Jul;48(7):549-54. doi: 10.1017/S0012162206001162. PMID: 16780622

Recent systematic reviews

Effects of Hippotherapy on Postural Control in Children With Cerebral Palsy: A Systematic Review.
Peia F, Veiga NC, Gomes AP, Santos BND, Marques NMS, Glória IPDS, Goulardins JB
Pediatr Phys Ther 2023 Apr 1;35(2):202-210. Epub 2023 Mar 3 doi: 10.1097/PEP.0000000000000999. PMID: 36867588
Perinatal and long-term outcome of fetal intracranial hemorrhage: systematic review and meta-analysis.
Sileo FG, Zöllner J, D'Antonio F, Islam S, Papageorghiou AT, Khalil A
Ultrasound Obstet Gynecol 2022 May;59(5):585-595. doi: 10.1002/uog.24766. PMID: 34529308
Guillain-Barré syndrome associated with SARS-CoV-2 infection: a scoping review.
Medeiros KS, Macêdo LTA, Souza WF, Sarmento AC, Costa APF, Gonçalves AK
Rev Assoc Med Bras (1992) 2021 Feb;67(2):318-334. doi: 10.1590/1806-9282.67.2.20200716. PMID: 34406260
Classification of topographical pattern of spasticity in cerebral palsy: a registry perspective.
Reid SM, Carlin JB, Reddihough DS
Res Dev Disabil 2011 Nov-Dec;32(6):2909-15. Epub 2011 May 31 doi: 10.1016/j.ridd.2011.05.012. PMID: 21624819
A systematic review of the effectiveness of aerobic exercise interventions for children with cerebral palsy: an AACPDM evidence report.
Rogers A, Furler BL, Brinks S, Darrah J
Dev Med Child Neurol 2008 Nov;50(11):808-14. Epub 2008 Sep 22 doi: 10.1111/j.1469-8749.2008.03134.x. PMID: 18811714

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